Release Release of bone morphogenetic protein using amorphous calcium phosphate film as a carrier

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K06812
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Composite materials/Surface and interface engineering
• Research Institution: Tohoku University
• Principal Investigator: UEDA KYOSUKE 東北大学, 工学研究科, 准教授 (40507901)
• Co-Investigator(Kenkyū-buntansha): 成島 尚之 東北大学, 工学研究科, 教授 (20198394)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: インプラント / コーティング / 非晶質リン酸カルシウム / 骨形成能 / 抗菌性

Outline of Final Research Achievements

The surface treatment process for both improving the bone compatibility and achieving antibacterial property on Ti implants was established by focusing on the dissolution of amorphous calcium phosphate (ACP). Bone morphogenetic protein (BMP) was loaded on the surface of the ACP coating films fabricated by RF magnetron sputtering. Sustained release of BMP through the dissolution of ACP coating film was observed. Ag- and Ta- co-added ACP coating film was fabricated by controlling the composition of the target during the sputtering process. The dissolution of Ag-added ACP coating films in simulated body fluids was suppressed by the addition of Ta in the coating film. It was estimated that the long-term antibacterial activity and improving the bone formation of the Ti implants by the release of Ag ion and ACP coating films, respectively.

Free Research Field

医用材料工学

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた、ACPとタンパク質の複合化技術や元素添加によるACPの溶解性制御は、生体内溶解性ACPの新規活用方法を学術的根拠を基に提案するものである。これまで高分子材料が大半を占めていた薬剤輸送システムに対し、セラミックス系材料であるACPという新たな候補を与え、医療技術のブレークスルーに貢献できると考える。