2019 Fiscal Year Final Research Report

Development of decellularized medical materials for the anti-allergic agent search system in tissue engineering

Research Project

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Project/Area Number	17K06899
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Properties in chemical engineering process/Transfer operation/Unit operation
Research Institution	Fukuoka University
Principal Investigator	MISHIMA KENJI 福岡大学, 工学部, 教授 (40190623)
Co-Investigator(Kenkyū-buntansha)	シャーミンタンジナ福岡大学, 工学部, 助教 (00794182) 井上俊孝西九州大学, 健康福祉学部, 教授 (20274615) 志村英生福岡大学, 医学部, 教授 (80178996)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	超臨界流体 / 二酸化炭素 / 超音波 / 再生医療
Outline of Final Research Achievements	This is a study to decellularize organs and reconstruct the structural information of the extracellular matrix in order to create decellularized medical materials that can be used for the anti-allergic agent search system in tissue engineering. The implication of these antiallergic agents varied greatly depending on the individual, and there is a demand for regenerative medicine. There is a separate "model organ that reflects biological characteristics" that replaces drug testing, which places a heavy burden on patients. As a regenerative medical material, a cell-removed extracellular matrix derived from a living body is suitable for a scaffold for cell proliferation. We have developed a method for producing bioscaffold organs decellularized from organs of different mammals such as, pigs, etc. by using ultrasonic waves together with supercritical carbon dioxide, which is harmless to the living body and whose solvent properties are easy to control.
Free Research Field	化学工学
Academic Significance and Societal Importance of the Research Achievements	本研究は、脱化石資源が求められる国際社会で、高齢化社会における持続可能な高度技術を利用した高付加価値製品生産の基盤技術の創製である。生体に害がなく溶媒特性の制御が容易である超臨界二酸化炭素と超音波を併用し、生体複合材料調整に係わるナノ構造制御技術として、超臨界ナノ制御、ナノバブル、ナノ界面制御技術を開発した。従来の技術では、実用製品の機能・価格競争力の証明が課題となっている。本研究では、その課題解決策として、二酸化炭素と水が作り出すナノサイズの気液界面により、ナノメートルオーダーの微細構造制御を容易にし、有機溶媒を使用せず、安価で高機能性材料の創製を可能にする装置技術を提供した。