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2020 Fiscal Year Final Research Report

Physiological role of vesicular glutamate release from glial cells

Research Project

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Project/Area Number 17K07070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

MIYASHITA Tomoyuki  公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主席研究員 (70270668)

Project Period (FY) 2017-04-01 – 2021-03-31
Keywordsグリア細胞 / 小胞性グルタミン酸輸送体 / NMDA受容体 / Mg2+ ブロック / 連合学習 / ショウジョウバエ
Outline of Final Research Achievements

We identified a novel vesicular glutamate transporter (dvGluT2) expressed in Drosophila glial cells, suggesting that dvGluT2 is required for aversive associative learning, i.e., exocytosis of glutamate from glial cells is required for associative learning. Furthermore, it was found that the information of electric shock was input via NMDA receptors (NR) in the mushroom body (MB). In summary, we proposed a model in which electric shock induces vesicular exocytosis of glutamate in glia, and the released glutamate induces Ca2+ influx via NRs during the depolarization of postsynaptic MB neurons by odor stimulation.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

近年、グリア細胞は神経の可塑性に重要な役割を持つことが次々と明らかになってきている。しかし、本研究ではグリア細胞が、嫌悪の情報を記憶中枢に伝えているという全く新しいグリア細胞の機能を明らかにしたと考えている。さらに、連合学習における、無条件刺激が条件刺激に対して同時または、遅れて与えられたときのみ連合学習が成立するメカニズムを明らかにできたと考えている

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Published: 2022-01-27  

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