• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2019 Fiscal Year Final Research Report

Elucidation of the regulation of INK4 locus by long noncoding RNA and the oncogenic mechanism by the bankruptcy.

Research Project

  • PDF
Project/Area Number 17K07184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionKindai University

Principal Investigator

KOTAKE YOJIRO  近畿大学, 産業理工学部, 教授 (90531963)

Project Period (FY) 2017-04-01 – 2020-03-31
Keywordslong noncoding RNA / INK4 locus / CDK inhibitor p15 / CDK inhibitor p16 / cell cycle / cancer cells
Outline of Final Research Achievements

The aim of this study is to reveal the regulation of INK4 locus by long noncoding RNA (lncRNA) and the oncogenic mechanism by the bankruptcy. In this study, we showed that a novel lncRNA, LOIL (lncRNA on the INK4 locus) functions to promote the proliferation of human lung cancer and colorectal cancer cells. Furthermore, we revealed that LOIL represses the transcription of CDK inhibitors p15 and p16 on INK4 locus. We also showed that another lncRNA, SLOP functions to promote G1 phase progression of cell cycle via repressing p15 transcription.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、我々が同定したlncRNA LOILとSLOPが、INK4遺伝子座の転写抑制を介して各種癌細胞の増殖を促進することが明らかとなった。INK4遺伝子座は、多くのヒト癌で変異や転写抑制されていることが報告されていることから、この遺伝子座の転写抑制因子は癌化に関与している可能性が高いと考えられる。従って、LOILとSLOPは将来的に癌治療薬の分子標的や癌診断マーカーになる可能性が示唆された。

URL: 

Published: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi