2019 Fiscal Year Final Research Report
Basic study on antitumor effects of the extracts derived from novel brown algae with a cancer cell-specific cell death inducing effect.
| Project/Area Number |
17K07793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 抗腫瘍効果 / フコイダン |
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| Outline of Final Research Achievements |
Low molecular weight fucoidan extract (LMF) was examined the cancer cell-specific anti-tumor effects. As results, LMF treatment suppressed the expression of PD-L1, EGFR, and VEGF, etc. It was confirmed that LMF suppressed the properties of cancer cells. It was found that combined treatment of various anticancer drugs and LMF was effective. In addition, LMF enhanced the expression of death receptors Fas and DR4 (TRAILR1), and the activation of caspase-3 and 8 were observed by LMF treatment. It was suggested that LMF contributed the apoptosis induction in cancer cells.
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| Free Research Field |
食品科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、新奇褐藻由来抽出物である酵素消化低分子化フコイダン抽出物(LMF)がもつ、がん細胞特異的な抗腫瘍効果の検討を行ったものである。LMFによるがん細胞のがん形質抑制やがん細胞特異的なアポトーシスの誘導を明らかにしたことが学術的意義であり、抗がん剤とLMFの併用治療の有効性が示唆され、ゆきづまりを見せている化学療法の補助薬としての臨床応用が期待される点に社会的意義がある。
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