Pathogenesis study of neurological diseases in calves

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Obihiro University of Agriculture and Veterinary Medicine
• Principal Investigator: Kobayashi Yoshiyasu 帯広畜産大学, 畜産学部, 教授 (20301971)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 周産期脳障害 / 神経傷害マーカー / 低酸素マーカー / 小脳皮質変性症 / ウシ

Outline of Final Research Achievements

The present study revealed that periventricular leukomalacia, cerebral cortical necrosis, and bilateral focal symmetrical encephalomalacia (necrosis of basal ganglia) were seen also in cattle as perinatal brain damages. Fluoro Jade C, a nerve injury marker, Alzheimer precursor protein A4, an axonal degeneration marker, and Hypoxia inducible factor-1a and vascular endothelial growth factor, both a hypoxic marker, were useful for detecting these lesions. These markers were useful to visualize the lesions of an encephalopathy without obvious histopathological changes in some cases. Histopathological features of bovine cerebellar cortical degeneration were also clarified in the present research.

Free Research Field

獣医病理学

Academic Significance and Societal Importance of the Research Achievements

本研究により、これまで良く知られていなかった周産期脳障害がウシにも存在することが明らかになった。また、神経傷害マーカーや低酸素マーカーがウシでも適用できることを示すとともに、ウシの小脳皮質変性症の特徴所見を明らかにすることができた。これらの知見は、今後の症例診断に有用な情報を与えるものである。