Development of functional recognition molecules for oxidized nucleosides in a cell

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08212
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Showa Pharmaceutical University (2018-2019); Kyushu University (2017)
• Principal Investigator: FUCHI Yasufumi 昭和薬科大学, 薬学部, 特任助教 (40748795)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 分子認識 / 捕捉分子 / 8位酸化グアノシン

Outline of Final Research Achievements

In this study, several functional recognition molecules for 8-oxidized guanosine derivatives produced by oxidative stresses in biological systems have been developed. Actually, capture molecules or fluorescence probes targeted toward 8-nitroguanosine, 8-thioguanosine and 8-oxoguanosine have been designed, synthesized and evaluated. These functional molecules exhibited specific capture reactivity or fluorescence response for target nucleosides in the biomimetic condition. The functional molecules developed in this study are expected as specific and versatile probes for 8-oxidized guanosine derivatives.

Free Research Field

核酸化学

Academic Significance and Societal Importance of the Research Achievements

本研究で開発された「8位酸化グアノシンを標的とした機能性認識分子」は、検出プローブや創薬リードとしての学術的・社会的貢献が想定される。すなわち検出プローブとしては、8位酸化グアノシンの生体中での新たな機能性の発見など学術的知見の進展に貢献することが期待され、創薬リードとしては新たな作用メカニズムによる新薬開発への展開など社会的貢献も期待される。