The regulatory mechanism of Reelin and its importance in neuropsychiatric disorders

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: Kohno Takao 名古屋市立大学, 医薬学総合研究院(薬学), 講師 (70581742)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 樹状突起 / 神経細胞移動 / 脳 / プロテオリシス

Outline of Final Research Achievements

Reelin is an essential molecule for the formation of cerebral layered structures, and its hypofunction is involved in the onset of Alzheimer's disease and schizophrenia. In this study, we identified a novel membrane protein that binds to Reelin and functions as a co-receptor for canonical Reelin receptors. Moreover, we found that the activity of Reelin is regulated by multiple proteases and its suppression may be a therapeutic target for Alzheimer's disease.

Free Research Field

分子神経生物

Academic Significance and Societal Importance of the Research Achievements

本研究により、脳の形成や機能制御に重要な役割をもつリーリンに着目して研究をおこない。リーリンの新たな機能制御機構とその脳における重要性が明らかになった。本研究で得られた知見は、精神神経疾患の治療法開発につながると期待される。