Investigation of new blood purification therapy which enables efficient removal of protein-bound uremic toxins

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: Yamamoto Takehito 東京大学, 大学院薬学系研究科(薬学部), 講師 (00376469)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 血液透析 / 慢性腎臓病 / タンパク結合性尿毒素

Outline of Final Research Achievements

The protein-bound uremic toxins are known to increase the risk of cardiovascular diseases in patients with chronic kidney disease or undergoing hemodialysis. The aim of this study is to develop the new blood purification method which enables effective removal of protein-bound uremic toxins from the body by adding appropriate binders in the dialysate.
Throughout the 3 years of study period, the principal investigator has tried to evaluate the removal rate of protein-bound uremic toxins by in vitro hemodialysis system with dialysate supplemented with various binders. However, the principal investigator could not obtain sufficient data due to the difficulty in setting up the optimal experimental condition. Further study is needed to achieve the final goal of this study.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

本研究は、現状の血液浄化療法では除去が困難なタンパク結合性尿毒素を、透析液に結合剤を添加することにより効率的に除去可能とすることを目指したものである。種々の検討を行ったものの、研究期間内に十分な検証をするには至らなかったが、今後さらに検討を進めることで、タンパク結合性尿毒素の効率的な除去を可能とする新たな血液浄化療法の構築に繋がる基礎的知見を得ることが出来ると期待される。