2019 Fiscal Year Final Research Report
Effect of prenatal valproate exposure on astorcyte-regulated synaptic function
| Project/Area Number |
17K08478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 自閉症スペクトラム障害 / アストロサイト / バルプロ酸ナトリウム |
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| Outline of Final Research Achievements |
Neurodevelopmental change is examined in neuron co-cultured with astrocyte that is isolated from animal model of autism with prenatal exposure to valproic acid. The neuron co-cultured with autism model astrocyte demonstrated the increase in excitatory synaptic transmission compared with neuron co-cultured with normal astrocyte. The neuron co-cultured with autism model astrocyte did not show change in number of excitatory synapse. On the other hand, the neuron co-cultured with autism model astrocyte demonstrated the increased expression of molecules which are mediate synaptic vesicle release.Taken together, excitarotry synaptic transmission increased by co-culturing with ASD model astrocyte may be due to increased expression of molecules which are mediate synaptic vesicle release.
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| Free Research Field |
神経薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
自閉症スペクトラム障害（ASD）の有病率は、約１％以上あるとされているが、その治療法は確立されておらず、その病態機序も明らかではない。本研究成果は、ASDモデル動物由来のアストロサイトが神経細胞におけるシナプス機能異常を引き起こすことを示しており、ASDの病態機序にアストロサイトによる神経機能調節が関与していることを提案している。従って、ASDの治療法開発のため、アストロサイトを標的とした創薬の方向性を本研究成果は提案するものである。
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