2019 Fiscal Year Final Research Report
Regulation of pituitary hormone production and signal transduction via microRNA
Project/Area Number |
17K08558
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | National Center for Child Health and Development |
Principal Investigator |
Tanoue Akito 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 部長 (60301800)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Keywords | 下垂体 / miRNA / 成長ホルモン / Dgcr8 |
Outline of Final Research Achievements |
The purpose of this study was to identify the miRNAs involved in growth hormone (GH) production in the pituitary gland and to analyze their functions, and to examine their involvement in the growth of individuals. It was found that the mouse that miRNA deficient specifically in pituitary GH-producing cells have decreased body length and weight, decreased number of GH-producing cells, and decreased blood IGF level. As a result of comparing the GH-producing cell line and the GH-nonproducing cell line, multiple miRNAs highly expressed in the GH-producing cells were identified, and It was revealed that introduction of some miRNAs into GH non-producing cell lines induces GH production.
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Free Research Field |
実験薬理学、神経内分泌学
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Academic Significance and Societal Importance of the Research Achievements |
下垂体は内分泌系による生体恒常性維持において、中枢神経系と末梢標的器官とをつなぐ重要な内分泌器官である。したがって、下垂体の機能調節機構を明らかにすることは、ホルモンを介した成長制御、ストレス応答反応、生殖機能制御等を理解する上で、極めて重要な研究課題である。本研究でGH産生におけるmiRNAの機能の一端が明らかとなり、GH分泌不全等の下垂体機能不全の病因を理解することにもつながると期待される。
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