2019 Fiscal Year Final Research Report
Studies of the mechanism for the establishment of sexual differences in hippocampal learning processes
| Project/Area Number |
17K08577
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
長谷 都 聖マリアンナ医科大学, 医学部, 准教授 (20450611)
萩原 裕子 聖マリアンナ医科大学, 医学部, 助教 (90468207)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 海馬 / エストロジェン / シナプス / 空間学習 / LTP / 性分化 |
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| Outline of Final Research Achievements |
In rodents, sex steroid hormones control many functions regulated by the central nervous system. The sex difference in the brain functions is at least in part as the result of steroid hormone milieu during prenatal development and immediately after birth. We examined in the present study whether this sex steroid hormone milieu affected the sex specific alteration of hippocampal neuronal function by feeding experiences. As the results, we revealed that the sex specific alteration by the feeding experience in spatial learning regulated by the hippocampus was at least in part as the result of the sex difference in steroid hormone milieu immediately after birth.
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| Free Research Field |
生理学
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| Academic Significance and Societal Importance of the Research Achievements |
実験動物のラットなどの齧歯類は，脳によって調節される機能の少なくとも一部は性腺ステロイドホルモンに強く影響され，それは，出生時期の性腺ステロイドホルモン環境の違いによる脳の性分化の結果と考えられる。本研究から，性特異的な飼育環境による海馬機能の変容が，一部は出生時期の性腺ステロイドホルモン環境の違いによる性分化の結果である事がわかった意義がある。
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