2019 Fiscal Year Annual Research Report
Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer
| Project/Area Number |
17K08700
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| Research Institution | Iwate Medical University |
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Principal Investigator |
菅井 有 岩手医科大学, 医学部, 教授 (20187628)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 大腸癌 / 右側大腸癌 / コピー数異常 / メチル化 / TP53変異 / KRAS変異 |
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| Outline of Annual Research Achievements |
大腸癌では発生部位によって分子レベルの発生機序が異なっていることが報告されており、右側大腸癌ではmicrosatellite instability (MSI, MIN)型の癌が多く、左側大腸癌ではmicrosatellite stable (MSS)型の癌が多いことが明らかにされている。しかし右側発生の癌であってもMSS型の癌が60-70%を占めており、大腸癌の基本分子病型はMSS型 (CIN型)である。大腸癌の分子異常が発生部位で異なっていることを示すためにはMSS型の分子異常が左右の大腸癌で異なっていることを明らかにすることが必要である。本研究の成果として、1) TP53変異の頻度は左側大腸癌に有意に多く、KRAS変異の頻度は右側大腸癌に有意に多かった、2) 左側大腸癌では右側大腸癌より全体のコピー数異常の総和とgain lengthにおいて有意に大きかった。3) しかしメチル化には両群間には差異はなかった、4) Gainとして10q14.1-14.2に位置するCDK4/6が、copy neutral LOHとして3p24.3に位置するRARβ2遺伝子が候補遺伝子の1つとして示唆された、5) 最後にMSS型右側大腸癌はMSS型左側大腸癌と比較して高齢者が多かったが、組織学的違いはなかった、が示された。本研究によって、進行大腸癌におけるMSS型癌の発生部位における分子病理学的差異を明らかにすることができた。上記の結果は右側大腸癌と左側大腸癌間では病態が異なっていることを示唆しており、治療戦略においても重要な視点を与える可能性があると思われた。
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[Journal Article] Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme.2020
Author(s)
Ohashi R, Martignoni G, Hartmann A, Calio A, Segala D, Stohr C, Wach S, Erlmeier F, Weichert W, Autenrieth M, Schraml P, Rupp NJ, Ohe C, Otsuki Y, Kawasaki T, Kobayashi H, Kobayashi K, Miyazaki T, Shibuya H, Usuda H, Umezu H, Fujishima F, Furusato B, Osakabe M, Sugai T, etc
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Journal Title
Virchows Arch
Volume: 476
Pages: 409-418
DOI
Peer Reviewed / Open Access
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[Journal Article] Microvascular density under magnifying narrow-band imaging endoscopy in colorectal epithelial neoplasms.2020
Author(s)
Gonai T, Kawasaki K, Nakamura S, Yanai S, Akasaka R, Sato K, Toya Y, Asakura K, Urushikubo J, Fujita Y, Eizuka M, Uesugi N, Sugai T, Matsumoto T.
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Journal Title
Intest Res
Volume: 18
Pages: 107-114
DOI
Peer Reviewed / Open Access
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[Journal Article] Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum.2020
Author(s)
Nakanishi H, Sawada T, Kaizaki Y, Ota R, Suzuki H, Yamamoto E, Aoki H, Eizuka M, Hasatani K, Takahashi N, Inagaki S, Ebi M, Kato H, Kubota E, Kataoka H, Takahashi S, Tokino T, Minamoto T,Sugai T, Sasaki Y.
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Journal Title
PLoS One
Volume: 15
Pages: e229262-e229262
DOI
Peer Reviewed / Open Access
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[Journal Article] A diagnostic algorithm of magnifying endoscopy with crystal violet staining for non-ampullary duodenal epithelial tumors.2020
Author(s)
Toya Y, Endo M, Oizumi T, Akasaka R, Yanai S, Kawasaki K, Nakamura S, Eizuka M, Fujita Y, Uesugi N, Ishida K, Sugai T, Matsumoto T.
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Journal Title
Dig Endosc
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access
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[Journal Article] Upregulation of AEBP1 in endothelial cells promotes tumor angiogenesis in colorectal cancer.2020
Author(s)
Yorozu A, Yamamoto E, Niinuma T, Tsuyada A, Maruyama R, Kitajima H, Numata Y, Kai M, Sudo G, Kubo T, Nishidate T, Okita K, Takemasa I, Nakase H, Sugai T, Takano K, Suzuki H.
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Journal Title
Cancer Sci
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access
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[Journal Article] Clinical usefulness of magnifying colonoscopy for the diagnosis of ulcerative colitis-associated neoplasia.2019
Author(s)
Kawasaki K, Nakamura S, Esaki M, Kurahara K, Eizuka M, Nuki Y, Kochi S, Fujiwara M, Oshiro Y, Sugai T, Matsumoto T.
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Journal Title
JACC Basic Transl Sci.
Volume: 4
Pages: 234-247
DOI
Peer Reviewed / Open Access
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[Journal Article] UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells.2019
Author(s)
Niinuma T, Kitajima H, Kai M, Yamamoto E, Yorozu A, Ishiguro K, Sasaki H, Sudo G, Toyota M, Hatahira T, Maruyama R, Tokino T, Nakase H, Sugai T, Suzuki H.
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Journal Title
Clin Epigenetics.
Volume: 11
Pages: 70-70
DOI
Peer Reviewed / Open Access
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[Journal Article] Risk Factors for Post-gastric Endoscopic Submucosal Dissection Bleeding with a Special Emphasis on Anticoagulant Therapy.2019
Author(s)
Toya Y, Endo M, Oizumi T, Akasaka R, Yanai S, Kawasaki K, Nakamura S, Eizuka M, Fujita Y, Uesugi N, Sugai T, Matsumoto T.
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Journal Title
Dig Dis Sci.
Volume: 65
Pages: 557-564
DOI
Peer Reviewed / Open Access
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[Journal Article] The expression of gastrointestinal differentiation markers in extrahepatic cholangiocarcinoma: clinicopathological significance based on tumor location.2019
Author(s)
Ishida K, Osakabe M, Eizuka M, Tai S, Sugimoto R, Fujita Y, Katagiri H, Takahara T, Uesugi N, Nitta H, Sasaki A, Sugai T.
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Journal Title
Hum Pathol.
Volume: 92
Pages: 91-100
DOI
Peer Reviewed / Open Access
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[Journal Article] Classic Chromophobe Renal Cell Carcinoma Incur a Larger Number of Chromosomal Losses Than Seen in the Eosinophilic Subtype.2019
Author(s)
Ohashi R, Schraml P, Angori S, Batavia AA, Rupp NJ, Ohe C, Otsuki Y, Kawasaki T, Kobayashi H, Kobayashi K, Miyazaki T, Shibuya H, Usuda H, Umezu H, Fujishima F, Furusato B, Osakabe M, Sugai T, Kuroda N, Tsuzuki T, Nagashima Y, Ajioka Y, Moch H.
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Journal Title
Cancers (Basel).
Volume: 11
Pages: 1492-1492
DOI
Peer Reviewed / Open Access
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[Journal Article] Gastrointestinal involvement in patients with vasculitis: IgA vasculitis and eosinophilic granulomatosis with polyangiitis.2019
Author(s)
Kawasaki K, Nakamura S, Esaki M, Kurahara K, Eizuka M, Okamoto Y, Hirata T, Hirahashi M, Oshiro Y, Yanai S, Sato K, Toya Y, Maemondo M, Terayama Y, Sugai T, Matsumoto T.
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Journal Title
Endosc Int Open.
Volume: 7
Pages: 1333-1343
DOI
Peer Reviewed / Open Access
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[Journal Article] Sessile serrated polyp/adenoma (SSA/P) showed rapid malignant transformation in the final thirteen months - case report.2019
Author(s)
Amemori S, Yamano HO, Tanaka Y, Yoshikawa K, Matsushita HO, Takagi R, Harada E, Yoshida Y, Tsuda K, Kato B, Tamura E, Eizuka M, Sugai T, Adachi Y, Yamamoto E, Suzuki H, Nakase H.
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Journal Title
Dig Endosc.
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access
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[Journal Article] Elemental and mutational analysis of lung tissue in lung adenocarcinoma patients.2019
Author(s)
Chiba R, Morikawa N, Sera K, Ishida K, Nagashima H, Shigeeda W, Deguchi H, Tomoyasu M, Hosokawa T, Saito H, Sugai T, Yamauchi K, Maemondo M.
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Journal Title
Transl Lung Cancer Res.
Volume: 8
Pages: 224-234
DOI
Peer Reviewed / Open Access
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[Journal Article] Sarcomatoid change associated with epithelial-mesenchymal transition in mucinous tubular and spindle cell carcinoma of the kidney: a case report.2019
Author(s)
Sugimoto R, Uesugi N, Yamada N, Osakabe M, Fujita Y, Eizuka M, Kato R, Ishida K, Obara W, Nagashima Y, Sugai T.
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Journal Title
Int J Clin Exp Pathol.
Volume: 12
Pages: 2767-2771
Peer Reviewed
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[Presentation] Analysis of expression patterns of microRNAs in ovarian high-grade serous carcinoma.2019
Author(s)
Sato C, Osakabe M, Ito Y, Sato A, Nishiya M, Suzuki S, Sugimoto R, Fujita Y, Uesugi N, Ishida K, Baba T, Sugai T
Organizer
The 38th Sapporo International Cancer Symposium（第38回札幌国際がんシンポジウム
Int'l Joint Research
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