Towards an improvement in the low sensitivity to chemotherapy in ovarian clear cell carcinoma

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K08709
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Teikyo University
• Principal Investigator: Koike Ryoko 帝京大学, 医学部, 助手 (80535063)
• Co-Investigator(Kenkyū-buntansha): 坂本 優 公益財団法人佐々木研究所, 附属研究所, 副院長(移行) (20260101) ; 綾部 琢哉 帝京大学, 医学部, 教授 (00272568) ; 中川 俊介 帝京大学, 医学部, 講師 (70270874)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 卵巣明細胞腺癌 / 蛍光標識2次元ディファレンシャルゲル電気泳動法

Outline of Final Research Achievements

Fluorescence-labeled two-dimensional differential gel electrophoresis showed that the expression of lab-named protein 1 was higher in ovarian clear cell carcinoma cell lines 1 and 2, which are poor responders to paclitaxel, than in cell lines 3 and 4, which are good responders to paclitaxel. The expression of lab-name protein 1 was higher in cell line 1 and 2 than in cell line 3 and 4. Kaplan-Meier survival analysis of 39 cases of ovarian adenocarcinoma showed that there were no deaths in the group with low expression of lab name protein1.

Free Research Field

卵巣癌

Academic Significance and Societal Importance of the Research Achievements

卵巣明細胞腺癌ではラボネームprotein1が下がるとパクリタキセルの感受性が上がり、生命予後がよくなる可能性がある。