2019 Fiscal Year Final Research Report

Pathological features and histogenesis of interstitial pneumonia-related lung adenocarcinoma

Research Project

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Project/Area Number	17K08724
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Human pathology
Research Institution	Yokohama City University
Principal Investigator	OKudela Koji 横浜市立大学, 医学部, 准教授 (10326027)
Co-Investigator(Kenkyū-buntansha)	宮城洋平地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 所長 (00254194) 横瀬智之地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, その他 (10221665) 荒井宏雅横浜市立大学, 医学研究科, 客員講師 (10381493) 立石陽子横浜市立大学, 医学部, 助教 (20644438) 梅田茂明横浜市立大学, 附属病院, 助教 (30644439) 大橋健一横浜市立大学, 医学研究科, 教授 (40231203) 石川善啓横浜市立大学, 附属病院, 助教 (40384838) 禹哲漢横浜市立大学, 医学部, 講師 (90537177)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	病理学 / 肺腺癌 / 間質性肺炎 / 遺伝子異常 / 発癌経路
Outline of Final Research Achievements	[Purpose] The purpose of this study is to elucidate histogenesis of interstitial pneumonia-related lung adenocarcinoma (IP-LADC). [Methods] We focused on bronchiolar metaplasia that lines honeycomb lesions as the potential precursor for IP-LACD and investigated molecular alterations by comprehensive mutational analyses, digital PCR for KRAS mutations, immunohistochemistry for HNF4a, and bisulfite sequencing for TTF1 promoter to confirm metaplasia-LADC pathway. [Results] 1) Mutational burden, some KRAS point mutations, HNF4a-positve cell frequency, and the levels of TTF1 methylation increased in healthy part, metaplastic lesion, and IP-LADC in this order. [Conclusions] The results supported the notion that IP-LADC develops through bronchiolar metaplasia in honeycomb lesions.
Free Research Field	医学
Academic Significance and Societal Importance of the Research Achievements	間質性肺炎と肺癌の診療水準の向上に寄与する。