cell cell interaction with macrophages and lymphoma

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kumamoto University
• Principal Investigator: horlad hasita 熊本大学, 大学院生命科学研究部(医), 研究員 (00644840)
• Co-Investigator(Kenkyū-buntansha): 菰原 義弘 熊本大学, 大学院生命科学研究部(医), 准教授 (40449921)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: マクロファージ

Outline of Final Research Achievements

We clarified the importance of macrophages in various malignant tumors such as lymphoma. The expression of PD-L1 and CD163 in macrophages was increased by a cancer cell-derived factor, and it was revealed that these molecules contribute to tumor development.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍におけるマクロファージの役割を明らかにすることで、マクロファージを標的にした新しい治療法の開発につながることができる。