2019 Fiscal Year Final Research Report
cell cell interaction with macrophages and lymphoma
Project/Area Number |
17K08763
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Kumamoto University |
Principal Investigator |
horlad hasita 熊本大学, 大学院生命科学研究部(医), 研究員 (00644840)
|
Co-Investigator(Kenkyū-buntansha) |
菰原 義弘 熊本大学, 大学院生命科学研究部(医), 准教授 (40449921)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Keywords | マクロファージ |
Outline of Final Research Achievements |
We clarified the importance of macrophages in various malignant tumors such as lymphoma. The expression of PD-L1 and CD163 in macrophages was increased by a cancer cell-derived factor, and it was revealed that these molecules contribute to tumor development.
|
Free Research Field |
病理学
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Academic Significance and Societal Importance of the Research Achievements |
悪性腫瘍におけるマクロファージの役割を明らかにすることで、マクロファージを標的にした新しい治療法の開発につながることができる。
|