2019 Fiscal Year Final Research Report
Exacerbation mechanism of allergic skin inflammation
| Project/Area Number |
17K08803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
KITAJIMA MASAYUKI 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (00401000)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | アレルギー性皮膚炎 / TSLP / Th2 / IL-4 |
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| Outline of Final Research Achievements |
Thymic Stromal LymphoPoietin (TSLP) is an important mediator for the development of Th2-type allergic diseases, including atopic dermatitis (AD), in both human patients and murine models. However, the physiological role of TSLPR signaling by CD4 T cells in the development of skin inflammation by chronic allergen exposure remains to be elucidated. To investigate the role of TSLP in the progression of allergic inflammation, we used Tslpr conditional KO mice and a newly developed skin chronic inflammation model that features repetitive allergen challenge. In this study, we demonstrated that TSLPR on CD4 T cells is critical for development of chronic skin inflammation through enhancing IL-4 production and inhibiting cell death.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
申請者は新規慢性皮膚炎症マウスモデルを構築し、アレルギー性皮膚炎の重症化メカニズムの一端を明らかにした。このメカニズムは、早期炎症応答による炎症環境の変化がさらなる炎症重症化を導くという新しい概念を提示する意義深い成果である。本研究成果は、皮膚慢性炎症根治治療のための研究基盤となる炎症増悪化メカニズムのさらなる解明に繋がることが期待できる社会的意義の大きい成果でもある。
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