Clinical significance of chiral amino acid analysis in diabetic nephropathy/diabetic kidney disease

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K08979
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: SHIMIZU Miho 金沢大学, 保健管理センター, 助教 (10547136)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 糖尿病性腎症 / 糖尿病性腎臓病 / アミノ酸光学異性体

Outline of Final Research Achievements

Analysis of the association between estimated glomerular filtration (eGFR) rate and albuminuria at baseline or during follow-up and risk of end-stage kidney disease showed the utility of eGFR slope in type 2 diabetes with diabetic nephropathy/diabetic kidney disease as a surrogate endpoint for the renal outcome. Analyses of renal structural-functional relationships and outcomes showed that the impact of hypertension and renal arteriosclerosis on renal and cardiovascular outcomes and the impact of low hemoglobin level and interstitial fibrosis/tubular atrophy on renal outcome and mortality in type 2 diabetes with biopsy-proven diabetic nephropathy. Furthermore, the clinical significance of chiral amino acid analysis in type 2 diabetes with diabetic nephropathy/diabetic kidney disease was suggested.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

本研究では、糖尿病性腎症/糖尿病性腎臓病の臨床評価に有用な代替エンドポイント、組織機能連関が腎・心血管・生命予後に及ぼす影響に加えて、生体サンプルにおけるアミノ酸光学異性体測定の臨床的意義が示された。本研究の成果が、糖尿病性腎症/糖尿病性腎臓病の腎病変進展抑制ならびに予後改善に繋がることが期待される。