A novel diagnostic method using gastrointestinal endoscopy and transparency-increasing technology.

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09474
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: ONO Satoshi 東京大学, 医学部附属病院, 登録診療員 (40611934)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 透明化 / 病理 / 消化管

Outline of Final Research Achievements

The LUCID technology was effective to evaluate the deeper inside of the specimen obtained from the gastrointestinal tracts of animal models　anｄ human. Stacking of vertical images could construct the 3D image of specimen which can be used for evaluation of the structure of vessels and ducts in any slices. It was also revealed that the LUCID technology did not disturb the conventional histopathological assessment including the immunostaining.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

消化管腫瘍性病変に対する内視鏡治療検体を透明化して、その腺管構造や血管構造を立体的に評価することにより、最終的には病理学的な診断精度を高めることを目的とし、従来評価できなかった薄切断面以外での脈管侵襲の有無や深部構造を評価する手法を確立し、さらには将来的にはこの手法により得られた知見に基づいた新たな内視鏡機器の開発に繋げることができると考えられる。