establishment of novel imaging using LCTF for gastrointestinal cancer

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09475
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tottori University
• Principal Investigator: ISOMOTO Hajime 鳥取大学, 医学部, 教授 (90322304)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 光線力学診断 / LCTF / アミノレブリン酸 / 消化器悪性腫瘍 / がん細胞株

Outline of Final Research Achievements

With the aim of developing a high-accuracy diagnostic method for gastrointestinal malignant tumors, the clinical utility was examined by producing an actual and inverted microscope using a liquid crystal tunable filter (LCTF). In order to utilize PDD (photodynamic diagnosis) with 5-ALA (5-aminolevulinic acid), spectroscopic data of cancer cell lines and tumor clinical specimens were detected and analyzed using a microscope system attached to LCTF. As a result, wavelength spectrum data unique to malignant tumors could be obtained.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

今回得られた5-ALA（５アミノレブリン酸）および高分解能液晶LCTF付属顕微鏡システムを用いたPDD（光線力学的診断）における基礎データは、消化器悪性腫瘍の高精度診断法開発、すなわち悪性腫瘍の診断精度の向上・迅速化・自動化につながるものである。