Contribution of endotherial function and reactive oxygen species on the patogenesis of advanced heart failure

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K09488
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Amiya Eisuke 東京大学, 医学部附属病院, 特任講師 (80529090)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 重症心不全 / 血管内皮機能 / 栄養状態 / サルコペニア / 一酸化窒素 / 呼吸筋疲労 / 補助人工心臓

Outline of Final Research Achievements

I focused in the patients with left ventricular assist device (LVAD) and patients with congenital heart disease. I investigated the association between these patients and endothelial function, nutritional state or sarcopenia. The endothelial function in patients with LVAD was heavily determined by the kind of LVAD types. The clinical course of patients with LVAD could be predicted by the preoperative nutritional state, which was significantly related with right heart failure. In addition, The clinical course of patients with LVAD was heavily affected the presence of sarcopenia, which was exemplified by abdominal computed tomography.

Free Research Field

重症心不全

Academic Significance and Societal Importance of the Research Achievements

重症心不全状態は心臓以外の栄養状態や血管内皮機能、サルコペニアと病態が関連することを確認した。重症度の高さから心不全治療では十分に解決できないケースも多い中で、心臓以外の事象との関連を示すことによって、新たな介入ポイントを示唆する結果とも考えられ、今後の新たな治療戦略の開発につながることが期待される。