2019 Fiscal Year Final Research Report

Characteristics of cardiomyocyte from idiopathic pulmonary arterial hypertension and newly developed treatment

Research Project

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Project/Area Number	17K09498
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cardiovascular medicine
Research Institution	Okayama University
Principal Investigator	Akagi Satoshi 岡山大学, 医歯薬学総合研究科, 助教 (60601127)
Co-Investigator(Kenkyū-buntansha)	中村一文岡山大学, 医歯薬学総合研究科, 准教授 (10335630) 斎藤幸弘岡山大学, 大学病院, 医員 (20724454) 吉田賢司岡山大学, 医歯薬学総合研究科, 講師 (70532761) 伊藤浩岡山大学, 医歯薬学総合研究科, 教授 (90446047)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	特発性肺動脈性肺高血圧症 / iPS細胞 / 心筋細胞 / エネルギー代謝 / Warburg効果
Outline of Final Research Achievements	Idiopathic pulmonary arterial hypertension (IPAH) has characteristics with remarkable elevation of pulmonary artery pressure and dysfunction of right ventricular. Drugs for IPAH targets pulmonary arteries but did not directly target right ventricle. In this study we successfully created iPS cells from fibroblast obtained from patient with IPAH. Next, we successfully induced cardiomyocyte. Cardiomyocyte from IPAH patient had characteristic that energy metabolism depends on glycolysis under both normoxia and hypoxia.
Free Research Field	医学　循環器内科
Academic Significance and Societal Importance of the Research Achievements	特発性肺動脈性肺高血圧症の心筋細胞において、今回明らかになったエネルギー代謝の特性はこれまで知られていない。そのためこの特性に介入できる薬剤を開発できれば、新たな特発性肺動脈性肺高血圧症の治療薬として期待できる。