カテーテル人工弁留置後弁周囲逆流の診断精度向上とデバイス-ホスト連関に関する研究

2017 Fiscal Year Research-status Report

• Project/Area Number: 17K09505
• Research Institution: Yamaguchi University
• Principal Investigator: 立石 裕樹 山口大学, 医学部附属病院, 助教 (20793342)
• Co-Investigator(Kenkyū-buntansha): 和田 靖明 山口大学, 医学部附属病院, 講師 (50448297) ; 有吉 亨 山口大学, 医学部附属病院, 臨床検査技師 (60750627) ; 岡村 誉之 山口大学, 医学部附属病院, 助教 (70380011)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 人工弁周囲逆流（PVL) / 大動脈造影 / ビデオデンシトメトリー / 心臓超音波検査

Outline of Annual Research Achievements

1.心エコー上のPVL、大動脈造影上におけるビデオデンシトメトリーによるPVLの重症度診断、両者とも事前に診断法を作成し、再現性を確認後に全例解析を行った。
2.1の二つの診断法の重症度ごとの対応関係の評価を終え、現在までに当院でTAVIが施行された全例において、3.各モダリティで評価された重症度が予後に与える影響の評価を行った。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

心臓超音波検査上のPVL、大動脈造影上におけるビデオデンシトメトリーによるPVLの重症度診断と、その両者の関係を評価し、学会発表、論文作成を終えている。

Strategy for Future Research Activity

これまでの症例に対して多変量解析を行い、4.患者・解剖学的背景、手技的背景からPVL予測因子を抽出する。
最終的に5.術前術後のMSCTから人工弁とaortic rootのdevice-host interactionを評価し、PVLの予測シミュレーションを行う。

Causes of Carryover

30年度は主に学会発表、論文報告に使用する予定。

Research Products

• [Journal Article] The role of computed tomography in planning the appropriate X-Ray gantry for quantitative aortographic assessment of post-TAVI regurgitation. (2018)
  • Author(s): Hiroki Tateishi, Yosuke Miyazaki, Takayuki Okamura, Rodrigo Modolo, Mohammad Abdelghani, Osama I.I. Soliman, Tetsuro Oda, Akihito Mikamo, Yoshinobu Onuma, Patrick W. Serruys, Kimikazu Hamano, Masafumi Yano
  • Journal Title: Circulation Journal Volume: 印刷中 Pages: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inter-technique Consistency and Prognostic Value of Intra-Procedural Angiographic and Echocardiographic Assessments of Aortic Regurgitation after Transcatheter Aortic Valve Implantation. (2018)
  • Author(s): Hiroki Tateishi, Yosuke Miyazaki, Takayuki Okamura, Mohammad Abdelghani, Rodrigo Modolo, Yasuaki Wada, Shinichi Okuda, Ayumi Omuro, Toru Ariyoshi, Ayano Fujii, Tetsuro Oda, Tatsuhiro Fujimura, Takuma Nanno, Akihito Mikamo, Osama I.I. Soliman, Yoshinobu Onuma, Kimikazu Hamano, Masafumi Yano, Patrick W. Serruys.
  • Journal Title: Circulation Jounal Volume: 印刷中 Pages: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Completion of inter-technique comparison of intra-procedural post-TAVI aortic regurgitation assessments (2018)
  • Author(s): Hiroki Tateishi, Takayuki Okamura, Yasuaki Wada, Shinichi Okuda, Ayano Fujii, Ayumi Omuro, Toru Ariyoshi, Tetsuro Oda, Yoriomi Hamada, Akihito Mikamo, Kimikazu Hamano, Masafumi Yano
  • Organizer: EuroPCR 2018
  • Int'l Joint Research
• [Presentation] Inter-modal and clinical validation of intra-procedural echocardiographic and angiographic assessments of aortic regurgitation after TAVI. (2017)
  • Author(s): Hiroki Tateishi, Takayuki Okamura, Yasuaki Wada, Shinichi Okuda, Ayano Fujii, Yosuke Miyazaki, Mohammad Abdelghani, Ayumi Omuro, Toru Ariyoshi, Tetsuro Oda, Tatsuhiro Fujimura, Yoshinobu Onuma, Patrick W Serruys, Akihito Mikamo, Kimikazu Hamano, Masafumi Yano
  • Organizer: EuroPCR 2017
  • Int'l Joint Research
• [Presentation] TAVI後人口弁周囲逆流の大動脈造影と心臓超音波上の重症度評価の比較・相関とアウトカムへの影響の検討 (2017)
  • Author(s): Hiroki Tateishi, Takayuki Okamura, Yasuaki Wada, Shinichi Okuda, Ayumi Omuro, Toru Ariyoshi, Ayano Fujii, Tetsuro Oda, Tatsuhiro Fujimura, Akihito Mikamo, Kimikazu Hamano, Masafumi Yano
  • Organizer: CVIT 2017
  • Int'l Joint Research
• [Presentation] A comparison between the prognostic predictability of the echocardiographic assessment of the paravalvular leak immediately after TAVI and at discharge. (2017)
  • Author(s): Hiroki Tateishi, Takayuki Okamura, Yasuaki Wada, Shinichi Okuda, Ayano Fujii, Ayumi Omuro, Toru Ariyoshi, Tetsuro Oda, Tatsuhiro Fujimura, Akihito Mikamo, Kimikazu Hamano, Masafumi Yano
  • Organizer: London Valves 2017
  • Int'l Joint Research