Effects of pulmonary vasodilator in patients with Fontan circulation

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University
• Principal Investigator: Sakamoto Ichiro 九州大学, 大学病院, 学術研究員 (90616616)
• Co-Investigator(Kenkyū-buntansha): 筒井 裕之 九州大学, 医学研究院, 教授 (70264017)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: Fontan循環 / 酸素

Outline of Final Research Achievements

The purpose of this study was to investigate the effect of pulmonary vasodilators in patients with Fontan surgery for functional single ventricular, the most severe congenital heart disease. Initially, we were thinking about the usefulness of pulmonary vasodilators, but the results of the nitric oxide tolerance test during cardiac catheterization were not good result. However, in the oxygen inhalation during cardiac catheterization using nasal oxygen administration of 2 L / min, not only the oxygen saturation was improved, but the central venous pressure was also reduced.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

確立した治療方法のないFontan術後の患者に対して、急性効果ではあるが、Fontan手術後遠隔期の予後不良因子である「低酸素血症」と「中心静脈圧上昇」の2つを一つの治療で改善できる可能性を示すことができた。