Role of mitochondrial import machinery in cardiac remodeling and its application for treatment

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09581
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University
• Principal Investigator: Shouji Matsushima 九州大学, 大学病院, 助教 (80552869)
• Co-Investigator(Kenkyū-buntansha): 筒井 裕之 九州大学, 医学研究院, 教授 (70264017) ; 井手 友美 九州大学, 医学研究院, 准教授 (90380625)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 心不全 / ミトコンドリア / 蛋白取込 / 酸化ストレス

Outline of Final Research Achievements

In this study, we iaimded to eludicate the role of Tom/Tim complex in cardiac remodeling. In post-infarted hearts, Tim44 protein levels were decreased. Overexpression of Tim44 attenuated left ventricular dilatation and dysfunction, increaseed mitochondiral SOD, and decreased protein carbonylation. In contray, Tim44 knokout demonstrated the opposite effects. These data indictate that Tim44 play a protective role in cardiac remodeling by incraseding import of SOD into mitochondia.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

本研究により心筋リモデリングの病態理解が進むのみならず、ミトコンドリア取り込み機能の役割が明らかになり、新たな心不全治療戦略に発展する可能性を有している。