Elucidation of ectopic expression of fatty acid-binding protein 4 in endovascular injury and application to clinical therapies

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09594
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: Furuhashi Masato 札幌医科大学, 医学部, 講師 (20563852)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 脂肪酸結合タンパク / 血管内皮細胞 / 血管傷害

Outline of Final Research Achievements

Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes and macrophages and plays significant roles in the development of insulin resistance and atherosclerosis. The present study demonstrated that FABP4 was ectopically induced in endothelial cells by cellular senescence and vascular injury. Furthermore, secreted FABP4 from injured vascular endothelial cells promoted inflammatory response in several cells, proliferation and migration in vascular smooth muscle cells, and endothelial dysfunction in vascular endothelial cells, leading to the development of neointima formation after vascular injury.

Free Research Field

循環器、代謝

Academic Significance and Societal Importance of the Research Achievements

血管内皮傷害時における異所性発現型FABP4の発現機構と局所分泌されるFABP4の作用の包括的な解明により、血管炎や冠動脈インターベンションなどで問題となる再狭窄予防に対する新規治療法に応用できる可能性がある。