2017 Fiscal Year Research-status Report
Aging deteriorates the function of lung stem cells, but it can be restored by calorie restriction.
| Project/Area Number |
17K09666
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
ヒガブ中井 アハマド 慶應義塾大学, 医学部(信濃町), 特任講師 (00507915)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Keywords | lung stem cells / rachea stem cells / calorie restriction / aging |
|---|
| Outline of Annual Research Achievements |
We have identified the effect of aging on lung tissue stem cells. We found that aging reduced number of basal stem cells in the trachea. We have achieved a successful calorie restriction protocol that caused both young and old mice to lose weight. We found that calorie restriction increased the number of basal stem cells in the trachea both in young and old mice.
We successfully created a 3D cell culture technique that could mimic the in vivo calorie restriction.
|
| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
The calorie restriction protocol went successfully so we did not need to repeat it several times to adjust.
Samples collected showed clear statistical significance.
|
| Strategy for Future Research Activity |
We will examine the roles played by Sirt and mTOR genes, that are known to be related to calorie management. We will verify their roles in animal samples and in 3D culture system.
|
| Causes of Carryover |
ほとんど残っていません。
|
Research Products
(2 results)
