Role of downstream molecules of natriuretic peptides on podocytes in chronic kidney disease

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09697
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kyoto University
• Principal Investigator: YOKOI HIDEKI 京都大学, 医学研究科, 講師 (90378779)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: ポドサイト / ナトリウム利尿ペプチド / アルドステロン / 抗糸球体基底膜腎炎

Outline of Final Research Achievements

I focused on matrixi metalloproteinase-10 (MMP-10) which is increased in glomeruli by deletion of natriuretic peptide receptor. MMMP-10 was increased at the proliferative lesions in the renal biopsy specimen. ALDO, which means aldosterone infusion, heninephrectomy and high salt diet, stimulated systemic GC-A and MMP-10 double knockout (KO) mice exhibited less glomerular injury and albuminuria. In addition, podocyte-specific GC-A KO and MMP-10 KO double KO mice also showed similar results.
In conclusion, inhibition of MMP-10 could be a potential target against renal injury.

Free Research Field

腎臓病学

Academic Significance and Societal Importance of the Research Achievements

腎障害の程度とMMP-10発現が相関しうるデータは腎疾患においてMMP-10がマーカーとなりうる可能性を示唆している。今後血中や尿中MMP-10が疾患活動性マーカーになりうるか検討が必要である。
また、MMP-10抑制が腎疾患を軽減させる可能性は今後の創薬標的となりうる可能性を示唆している。