2019 Fiscal Year Final Research Report
Elucidation of the role of homeostatic inflammation in the AKI to CKD transition mechanism focusing on the time phase changes
| Project/Area Number |
17K09704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
桑原 孝成 熊本大学, 大学院生命科学研究部(医), 講師 (00393356)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | AKI / CKD |
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| Outline of Final Research Achievements |
We examined the role of MRP8 in each phase of the transition process from CKD to CKD. Eight to nine week-old male MRP8 knockout mice and control mice were subjected to left renal ischemia-reperfusion injury for 30 minutes without right nephrectomy. Macrophages were sorted using FACS analysis 2, 7 and 16 days after kidney injury, and then inflammation- and fibrosis-related molecules were analyzed by real-time PCR. As a result, no difference between groups was observed between the MRP8 knockout mouse and the control mouse.
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| Free Research Field |
腎臓
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| Academic Significance and Societal Importance of the Research Achievements |
急性腎障害患者が慢性腎臓病へ移行する過程で、TLR4に関連する炎症が関与していることは示唆されるものの、TLR4リガンドであるMRP8と腎障害慢性化との間に明確な関連を見出す結果には至らなかった。
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