2019 Fiscal Year Final Research Report
Dynamics of innate immune cells per se in autoimmune CNS disorders
Project/Area Number |
17K09776
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
|
Research Institution | Niigata University |
Principal Investigator |
KAWACHI Izumi 新潟大学, 医歯学系, 准教授 (40432083)
|
Co-Investigator(Kenkyū-buntansha) |
豊島 靖子 新潟大学, 脳研究所, 准教授 (20334675)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Keywords | 視神経脊髄炎 / 多発性硬化症 / アストロサイト / 自然免疫 |
Outline of Final Research Achievements |
Neuromyelitis optica (NMO) is an autoimmune CNS disorder, which is characterized by aquaporin-4 water channel (AQP4) autoantibodies. Based on our pathological study using autopsied samples from NMO cases, CNS lesions at initial/early active stages in NMO included some granulocytes, interleukin-17-producing T cells and macrophages. These data suggest that these cells might provide initial signals, which induce entry of AQP4 autoantibodies from the outside of CNS via blood-brain barrier, and contribute active CNS lesions in NMO.
|
Free Research Field |
神経内科学
|
Academic Significance and Societal Importance of the Research Achievements |
視神経脊髄炎はアクアポリン4自己抗体と補体が関連する中枢神経系自己免疫疾患であり, 本邦に多い指定難病の一つである. 早期病変にTH17/TC17をはじめとした新たな炎症向性リンパ球・顆粒球と炎症向性マクロファージ・ミクログリアを新たに見出した. 同細胞を抑制する分子標的治療の開発に向けた病態基盤の一部を確立したという点で意義があると考えられる.
|