The skin disease related joint symptoms and internal organ involvement

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Mie University
• Principal Investigator: Yamanaka Keiichi 三重大学, 医学系研究科, 教授 (70314135)
• Co-Investigator(Kenkyū-buntansha): 欠田 成人 三重大学, 医学系研究科, リサーチアソシエイト (00422866) ; 近藤 誠 三重大学, 医学部附属病院, 講師 (40464169)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 尋常性乾癬 / アトピー性皮膚炎 / 皮膚炎モデルマウス / サイトカイン / 心血管病変 / 脂質代謝異常 / 全身性アミロイドーシス

Outline of Final Research Achievements

The prevalence of skin diseases such as psoriasis vulgaris and atopic dermatitis has been increasing and has become a social problem. Since skin is one of the largest immune organs, inflammatory cytokines produced from inflamed skin affect the internal organs. We used an original mouse model of spontaneous dermatitis to investigate the details of cerebrovascular lesions, arthritis, and amyloidosis induced by excessive production of IL-1 from lesions of skin inflammation. The involvement of IL-17 and the usefulness of anti-IL-17 antibody was also investigated.

Free Research Field

皮膚免疫、皮膚炎症、サイトカイン

Academic Significance and Societal Importance of the Research Achievements

アトピー性皮膚炎や尋常性乾癬等の患者は年々増加し、その内臓病変の生命予後への影響、関節炎の合併は注目を浴びており、本研究結果を社会に周知する効果は非常に大きく社会に貢献できる可能性が極めて高い。