2019 Fiscal Year Final Research Report
Dynamic dissection of anti BP180 IgE antibodies in bullous pemphigoid
| Project/Area Number |
17K10249
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka City University |
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Principal Investigator |
TATEISHI CHIHARU 大阪市立大学, 大学院医学研究科, 准教授 (40597308)
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| Co-Investigator(Kenkyū-buntansha) |
小澤 俊幸 大阪市立大学, 大学院医学研究科, 准教授 (50570602)
鶴田 大輔 大阪市立大学, 大学院医学研究科, 教授 (90382043)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 水疱性類天疱瘡 / 抗BP180IgE抗体 |
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| Outline of Final Research Achievements |
In bullous pemphigoid (BP), it was possible to observe in a time-dependent fashion using Live cell imaging method that the anti BP IgE antibody binds with BP180, followed by the encapsulation of the anti BP180 IgE antibody, and that BP180 also encapsulates after the anti BP IgE antibody combines with BP180. These results suggest that anti BP180 IgE antibodies play a role in the pathogenesis of BP.
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| Free Research Field |
皮膚科
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| Academic Significance and Societal Importance of the Research Achievements |
水疱性類天疱瘡（BP)において抗BP180IgE抗体が、病態形成に何らかの関与を果たしていることが示唆された。
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