Role of IER5-HSF1 axis in malignant melanoma carcinogenesis

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10261
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Japan Organization of Occupational Health and Safety Japan Bioassay Research Center
• Principal Investigator: Yamano Shotaro 独立行政法人労働者健康安全機構 日本バイオアッセイ研究センター(試験管理部、病理検査部), その他部局等, 主任研究員 (80614528)
• Co-Investigator(Kenkyū-buntansha): 大木 理恵子 国立研究開発法人国立がん研究センター, 研究所, 独立ユニット長 (70356252)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: IER5 / HSF1 / melanoma / NLS

Outline of Final Research Achievements

The purpose of this study is to clarify the function of IER5 and the role of the IER5-HSF1 pathway in melanoma, a type of skin cancer with a poor prognosis. Re-analyse of the TCGA database revealed a poor prognosis in the IER5 high expression group, especially in the group of malignant melanoma patients with BRAF mutations. The evaluation of lung metastasis of IER5KO strain using mouse melanoma cell line B16F10 suggested that IER5 may have an important role in cancer metastasis. In addition, it was revealed that the IER5 protein has one-bipartile type Nuclear localization signal.

Free Research Field

癌研究

Academic Significance and Societal Importance of the Research Achievements

本研究は悪性黒色腫の治療及び予防を最終目標とした基礎研究であり、本研究成果は将来的に悪性黒色腫患者における治療薬の開発、予後予測、予防等の観点から有益な情報になることを期待する。