2019 Fiscal Year Final Research Report
Identification of a biomarker for pathophysiology of schizophrenia using Kv3.1/3.2 gene mutations
| Project/Area Number |
17K10320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
白川 治 近畿大学, 医学部, 教授 (40243307)
細見 史治 近畿大学, 医学部, 助教 (40580783)
川久保 善宏 近畿大学, 医学部, 助教 (40716429)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 統合失調症 / 前頭前野 / 聴性定常反応 / 安静時脳血流 / NIRS |
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| Outline of Final Research Achievements |
We measured the auditory steady state response (ASSR) using electroencephalography (EEG) and the cerebral blood flow at rest using near-infrared spectroscopy（NIRS）to identify a biomarker for the pathophysiology of the prefrontal cortex in schizophrenia. In the analysis of the cerebral blood flow during resting-state, we applied the methods of the amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF), which have been used in fMRI studies to quantify the resting-state blood flow, to the NIRS data. We found that both ALFF and fALFF were decreased in the medial prefrontal cortex of the chronic patients with schizophrenia, and that the ALFF was negatively associated with the symptoms of auditory hallucinations in the patients.
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| Free Research Field |
精神医学
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| Academic Significance and Societal Importance of the Research Achievements |
従来PETやfMRIなどの大掛かりな設備が必要であった安静時脳血流の測定を、簡便な検査手技であるNIRSを用いておこなえることが示されたことは、安静時脳血流測定法の臨床現場への有用性を高めることができる点において有意義である。また、検査課題への取り組みに難を抱えやすい統合失調症患者にとって、こうした負担の少ない検査を用いて病態研究に用いることができることは、今後のバイオマーカー開発にとって有用なものとなる。
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