Practical Applications of Optical Topography in the Clinical Evaluation of Schizophrenia

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10330
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tottori University
• Principal Investigator: PU Shenghong 鳥取大学, 医学部, 助教 (70739789)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 統合失調症 / 前頭葉機能 / 認知機能 / NIRS

Outline of Final Research Achievements

The aim of this study was to identify data-driven biotypes of schizophrenia, which may help clarify diagnostic heterogeneity. Patients in each subgroup (%) versus HC showed a stepwise pattern of cortical functional alterations. Neurocognitive impairment in each subgroup accompanied frontal-temporal functional alterations. Subgroup 1 showed deficits in verbal memory, working memory, verbal fluency, or attention and information processing speed (5/6) domains of the Brief Assessment of Cognition in Schizophrenia. Subgroup 2 showed dysfunction in all domains. Subgroup 3 showed dysfunction in the attention and information processing speed domain. Three subtypes of frontal-temporal functional abnormalities exist in patients with schizophrenia, with widespread abnormalities associated with more neurocognitive impairments. Elucidation of the heterogeneity of schizophrenia may inform the development and optimization of subtype-specific treatment approaches.

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

今回の研究成果は科学雑誌に投稿することで世界の科学者・創薬メーカーに知見を広め、認知機能を高めるための新たな介入法の開発に貢献できる可能性がある。また、学会・講演などの機会を利用して研究内容を発表できた。