Development of new liver tumor diagnostic method using Gd-EOB-DTPA and ICG

2021 Fiscal Year Final Research Report

• Project/Area Number: 17K10393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: Akai Hiroyuki 東京大学, 医科学研究所, 准教授 (80770437)
• Co-Investigator(Kenkyū-buntansha): 桐生 茂 国際医療福祉大学, 医学部, 教授 (20313124)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: ガドリニウム造影剤

Outline of Final Research Achievements

In this study, we attempted to develop a new liver tumor diagnostic method using Gd-EOB-DTPA (hereinafter referred to as EOB) and ICG. Although, the effect of ICG administration on the inhibition of EOB uptake into the liver was stronger than expected. So, the development of an administration method useful for differentiating liver tumors was not realized.
We published multiple sub-papers, and found that ICG inhibits EOB liver accumulation and excretion (Invest Radiol 2017:441-5), and that EOB causes transient tachypnea (Eur Radiol 2018:4128-33), and that gadolinium brain deposition does not affect mouse movement or behavior (Radiology 2021:409-16).

Free Research Field

放射線診断学

Academic Significance and Societal Importance of the Research Achievements

Gd-EOB-DTPAの基礎的な検討を通して、同造影剤の臨床応用の一助となったと考えられる。
また、ガドリニウムの脳沈着はガドリニウム造影剤の安全性を考え上で重要な懸念となるが、少なくともマウスにおいては運動や行動に影響を及ぼさないことが確認されたことで、ガドリニウム造影剤の安全性に関する新たな治験が積み重なったと考えられる。