2019 Fiscal Year Final Research Report

Transvenous radiofrequency ablation system for the treatment of primary aldosteronism.

Research Project

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Project/Area Number	17K10431
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	Kei Takase 東北大学, 医学系研究科, 教授 (60361094)
Co-Investigator(Kenkyū-buntansha)	清治和将東北大学, 大学病院, 講師 (50400247) 中村保宏東北医科薬科大学, 医学部, 教授 (80396499) 佐藤文俊東北大学, 医学系研究科, 特任教授 (70343051) 森本玲東北大学, 大学病院, 准教授 (30547394)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	原発性アルドステロン症 / IVR / 高血圧 / ラジオ波焼灼術 / 副腎静脈サンプリング
Outline of Final Research Achievements	We initially developed flexible type metallic ablation catheter with coop-tip system which can be inserted via a guiding sheath using over-the-wire technique. We evaluated electrical and mechanical safety, reachability to left adrenal vein via femoral vein, and ablative volume to make improvement of the system. The ablation performance was evaluated by gel-model study and ex-vivo ablation of bovine adrenal gland to establish dosimetry table. Ablation volume under blood perfusion to adrenal gland will be evaluated by in-vivo ablation of porcine adrenal grand, in which protocol of blood pressure stabilization during the ablation should also be established. Reachability of the system to human adrenal gland was also evaluated by using a real-size vascular model based on 3D-CT data. After development of this system, most of the primary aldosteronism patients will be treated low-invasively leading to reduction of severe cardiovascular complications and medical cost.
Free Research Field	放射線診断学
Academic Significance and Societal Importance of the Research Achievements	高血圧の原因となる原発性アルドステロン症という疾患を、血管から入れた細いカテーテルを用いて体に優しい治療を行なうための基礎的開発と検証を行なうことができた。将来の高血圧に関連した脳卒中、心筋梗塞、腎不全といった医療費を圧迫する合併症を本治療により未然に防ぐことは、薬剤費の低減を含む医療費削減をしながら、国民の健康増進に寄与すると考える。若年性高血圧も来す本疾患の根治は、働き盛りの合併症を防止することで労働力確保にも貢献する。