2019 Fiscal Year Final Research Report
Experimental study on the immunostimulatory effects by combination of OK432 with hepatic artery embolization therapy or cryotherapy
| Project/Area Number |
17K10436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉田 耕太郎 金沢大学, 医学系, 助教 (30645130)
土屋 弘行 金沢大学, 医学系, 教授 (40227434)
南 哲弥 金沢医科大学, 医学部, 教授 (60436813)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 免疫賦活 / 凍結療法 / 動注 |
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| Outline of Final Research Achievements |
We tried to develop new treatments that cause the abscopal effect by combining OK-432 with hepatic artery embolization therapy or cryotherapy. The verification of hepatic arterial embolization with the emulsion of OK-432 and lipiodol was abandoned because selective hepatic artery embolization of rabbits resulted in unexpectedly large infarction, and immunostimulation could not be expected. We have developed a simple freezing system for animal experiments and confirmed its cooling performance. Using the freezing system, we performed the combination therapy of OK-432 local injection and cryotherapy on the rabbit VX2 liver and subcutaneous tumor models, but the abscopal effect could not be confirmed.
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| Free Research Field |
放射線医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で動物実験用に作成し冷却性能を確認した凍結システムは、簡便に作成し凍結療法を行うことができる。これを用いることにより、臨床応用の拡大が期待されている凍結療法に関して、今後さらなる探索的実験を進めることが可能となった。また、ウサギ肝動脈は容易に攣縮が生じてヒトでのTAEと異なり比較的強い塞栓となることがわかり、ウサギ肝臓を用いた経血管インターベンション実験を行っていくうえでの課題が判明した。
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