Novel method for the evaluation of hepatic function befoe and after PTPE

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10442
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagawa University
• Principal Investigator: Sanomura Takayuki 香川大学, 医学部, 助教 (80629080)
• Co-Investigator(Kenkyū-buntansha): 奥田 花江 香川大学, 医学部, 助教 (10437692) ; 岡野 圭一 香川大学, 医学部附属病院, 准教授 (20314916) ; 久冨 信之 香川大学, 医学部, 准教授 (20552045) ; 山本 由佳 香川大学, 医学部, 准教授 (30335872) ; 西山 佳宏 香川大学, 医学部, 教授 (50263900)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: PTPE / 肝予備能評価 / 99mTc-GSA肝シンチグラフィ

Outline of Final Research Achievements

Kinetic modeling of Tc-99m GSA measures the total amount of asialoglycoprotein receptor within a subject's liver. The purpose of this study was to evaluate the usefulness of kinetic analysis using dynamic SPECT/CT for assessment of hepatic function. Applying a two-compartment three-parameter model K1, k2 and k3 were obtained. Correlations were determined between these kinetic parameters and the results of biochemical liver function tests which include indocyanine green retention rate at 15 min (ICGR15), serum bilirubin, serum albumin, cholinesterase, prothrombin time, and platelet. The K1 and k3 values correlated with ICGR15, serum albumin and cholinesterase. Kinetic analysis using asialoglycoprotein receptor scintigraphy with Tc-99m GSA dynamic SPECT/CT might be useful for assessment of hepatic function. Tc-99m GSA SPECT/CT showed that PTPE induces a shift in hepatic function from the embolized part to the nonembolized part of the liver.

Free Research Field

IVR

Academic Significance and Societal Importance of the Research Achievements

肝予備能検査としてICGR15や99mTc-GSA肝シンチグラフィがある。今回ダイナミックSPECT検査法とコンパートメントモデル解析法を組み合わせ、局所肝機能を客観的かつ定量的に評価できる方法を考案した。考案された新たな定量指標はICGR15と相関し、また、術後肝不全の予測に有用である可能性が示唆された。また、PTPEに伴う局所肝機能の病態評価にも有用である。