Development of new IVR treatment using nanotechnology combined with molecular imaging

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10450
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nara Medical University
• Principal Investigator: NISHIOFUKU HIDEYUKI 奈良県立医科大学, 医学部, 講師 (80458041)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: Interventional radiology / ナノテクノロジー / 塞栓術

Outline of Final Research Achievements

The aim is to determine the tumor immune cell landscape after transcatheter arterial bland embolization in a clinically relevant rat HCC model.Results: TAE induces increased infiltration of Th17 cells in liver tumors when compared with controls 14 d after treatment (p = 0.02). A similar pattern was observed in the spleen (p < 0.001), indicating both local and systemic effect. Conclusion: Transcatheter hepatic arterial bland embolization induces local and systemic increased infiltration of Th17 cells and expression of their signature cytokine IL-17. In a simulated post-embolization environment, IL-17 significantly reduced McA-RH7777 cell migration.

Free Research Field

Interventional radiology

Academic Significance and Societal Importance of the Research Achievements

本研究は、IVR技術を用いて肝腫瘍への新規治療法を開発することである。これまでの研究でナノ粒子が腫瘍に選択的に効果発現をすることを報告してきたが、今回はmicrosphereを用いた場合の組織学的、画像的評価を行った。抗がん剤の分布をイメージング化し、さらに免疫学的、組織学的変化について検討した。今後ナノ粒子の研究と融合させていくことで新規治療法の開発につなげていく基盤の構築に繋がった。