Association carcinogenesis with oral microbiota in colorectal cancer

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10629
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Kondo Satoru 三重大学, 医学部附属病院, 医員 (60763737)
• Co-Investigator(Kenkyū-buntansha): 問山 裕二 三重大学, 医学系研究科, 准教授 (00422824) ; 奥川 喜永 三重大学, 医学部附属病院, 講師 (30555545) ; 楠 正人 三重大学, 医学系研究科, 教授 (50192026)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 大腸癌 / 潰瘍性大腸炎 / 腸内細菌 / マイクロサテライト不安定性

Outline of Final Research Achievements

Specific miRNAs to be methylated and DMRs in rectal mucosal in patients with UC could be used to identify patients with UC at greatest risk for developing UC-CRC. Fusobacterium infection was detected in CRC tissues. Furthermore, Fusobacterium infection was significantly associated with MSI-H compared to non-MSI-H. Unfortunately, it is difficult to detect the oral microbiota and we could not process comprehensive analysis of oral microbiota.

Free Research Field

消化器外科学

Academic Significance and Societal Importance of the Research Achievements

本研究結果を用いることで、潰瘍性大腸炎患者における潰瘍性大腸炎関連大腸癌の発癌予測マーカーとなり得るほか、MSI－H大腸癌における発癌機序に腸内細菌が関与している新たな可能性が示唆された。