Exploratory research of driver gene mutation and drug sensitivity-related genes expression changes in hepatocellular carcinoma

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K10675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: UENO Masaki 和歌山県立医科大学, 医学部, 講師 (90405465)
• Co-Investigator(Kenkyū-buntansha): 速水 晋也 和歌山県立医科大学, 医学部, 講師 (00468290) ; 川井 学 和歌山県立医科大学, 医学部, 准教授 (40398459) ; 山上 裕機 和歌山県立医科大学, 医学部, 教授 (20191190)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 腫瘍微小環境

Outline of Final Research Achievements

There was no significant association between the mutations in the driver genes and expressions in drug sensitivity-related genes. Furthermore, there was no significant relation between expressions of these drug sensitivity-related genes and the therapeutic effects of TACE therapy or molecular-targeted therapies.
Regarding the therapeutic effect in some patients received molecular-targeted therapies, there was a suggestive relation between the degree of infiltration of CD8-positive T cells around the tumor and the therapeutic effect. Therefore, not only gene expression of drug sensitivity-related genes, it was suggested that the condition of the tumor microenvironment strongly affects the therapeutic effect.

Free Research Field

肝臓外科

Academic Significance and Societal Importance of the Research Achievements

実臨床において薬剤治療効果を推測するには、腫瘍自体の遺伝子変異や、薬物感受性関連遺伝子の発現多寡のみならず、腫瘍微小環境の状態（抗腫瘍免疫の状態や、癌関連線維芽細胞の動態）などの解析を加える必要があることが分かった。