2019 Fiscal Year Final Research Report
Vasa Vasorum in Abdominal Aortic Aneurysm
| Project/Area Number |
17K10751
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TANAKA Hiroki 浜松医科大学, 医学部, 特任研究員 (50456563)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 優子 浜松医科大学, 医学部, 准教授 (20345812)
浦野 哲盟 浜松医科大学, 医学部, 教授 (50193967)
佐野 秀人 浜松医科大学, 医学部, 助教 (80623842)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 腹部大動脈瘤 |
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| Outline of Final Research Achievements |
Abdominal aortic aneurysm (AAA) is an inflammatory cardiovascular disease common among the elderly,1, 2) and whose pathogenesis is not fully understood.We sought to determine whether hypoperfusion of the adventitial VV could develop AAA.In this study, we can observed inflammatory cell and hypoxia in AAA tissue by two-photon microscopy.
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| Free Research Field |
心臓血管外科
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| Academic Significance and Societal Importance of the Research Achievements |
血管壁を栄養する微細な血流が腹部大動脈瘤(AAA)の発症や進展に関与することをより強く立証した。現況ではAAAの進展を制御する薬物療法はないが、微細な組織の血流改善が薬物の開発（あるいは治療適応の拡大）が新たな治療ターゲットになる。
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