2019 Fiscal Year Final Research Report

A new targeting therapy against periostin in lung cancer

Research Project

Project/Area Number	17K10805
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Respiratory surgery
Research Institution	Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Principal Investigator	Nakagawa Takayuki 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (10626261)
Co-Investigator(Kenkyū-buntansha)	佐藤賢一地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055) 玉井恵一地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (40509262)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	肺癌
Outline of Final Research Achievements	To clarify the role of cancer stem cell in lung cancer, we focus on the following points: 1. The role of periostin, localizes to storma, in lung cancer 2. The role of CD271, which we reported as a cancer stem cell-marker, in lung cancer. In conclusion, both periostin and CD271 promote the proliferation in lung cancer.
Free Research Field	呼吸器外科
Academic Significance and Societal Importance of the Research Achievements	本研究成果によって、肺癌の新たな治療標的が明らかになった。今後さらに検討を続けることで、肺癌幹細胞特異的な治療薬の開発につなげていく。