Development of a new material to prevent postoperative adhesions following pulmonary resection

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10809
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kyoto University
• Principal Investigator: Hamaji Masatsugu 京都大学, 医学研究科, 講師 (70782142)
• Co-Investigator(Kenkyū-buntansha): 伊達 洋至 京都大学, 医学研究科, 教授 (60252962)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 開胸 / 術後癒着 / 肺門部

Outline of Final Research Achievements

In canine models, using adult Beagle dogs, right thoracotomy and right upper lobectomy was performed (the upper lobe branched of pulmonary artery, pulmonary vein, and bronchus were ligated and divided using silk ties). We applied a bioabsorbable sheet composed of polyglycolic acid on the hilum, resulting in no improvement in postoperative adhesion. Then we applied "Adspray", which is commercially available, resulting a similar adhesion. Also we applied bioabsorbable sheet composed of oxidized cellulose, without significant effects on postoperative adhesion.

Free Research Field

胸部外科学

Academic Significance and Societal Importance of the Research Achievements

腹部手術において使用されている癒着防止材は、胸部手術特に肺切除術後の、肺門部における術後癒着防止にはほとんど効果が見られなかった。同じ整体吸収性素材でも、腹部における分解に要する時間と胸部において分解に要する時間は異なる、ということが推測されたため、腹部で使用されている素材とは全く異なる素材の開発が必要と考えられた。