Effects of Deferoxamine on intracerebral hemorrhage-induced brain injury

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kagawa University
• Principal Investigator: Okauchi Masanobu 香川大学, 医学部, 助教 (50615036)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 脳出血 / デフェロキサミン / 脳浮腫 / 脳萎縮

Outline of Final Research Achievements

We investigated whether Deferoxamine (DFX) is effective on brain injury after ICH in SD rats.Autologous whole blood (100 μL) was injected into the right basal ganglia. We explored optimal DFX dose, potential therapeutic time windows, and optimal therapeutic durations. DFX can reduce ICH-induced brain injury in rats and that a dose 50mg/kg is the optimal dose of DFX. DFX administration, when begun within 12 hours after ICH, reduced brain edema. DFX treatment started 2 hours after ICH and administrated for 7 days attenuated ICH-induced brain atrophy and neurological deficits. DFX attenuated brain atrophy and neurological deficits when begun within 24 hours and administrated for 7 days.

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

脳出血後の脳浮腫、脳萎縮および神経脱落症状は、患者の予後を左右する重大な因子である。鉄キレート剤であるDFXは脳出血後の脳損傷を改善できることが示唆された。本実験にてDFXの適切な濃度、投与期間、投与タイミングを示した。このデータは、今後脳出血に対するDFX治療が臨床応用されていく上で非常に重要である。