Investigating the prognostic factors of IDH wild-type glioma based on the comprehensive genomic analysis

2021 Fiscal Year Final Research Report

• Project/Area Number: 17K10862
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Nagoya University
• Principal Investigator: MOTOMURA KAZUYA 名古屋大学, 医学系研究科, 准教授 (30467295)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: 低悪性度神経膠腫 / IDH1 / 悪性転化

Outline of Final Research Achievements

The clinical significance of genetic lesions within each lower-grade gliomas (LGG) subtype has not been fully elucidated. In this study, they identified sets of subtype-specific genetic and clinicopathological markers for each WHO subtype. The study subjects were a large cohort of patients who were genotyped for known or putative driver mutations and copy number variations associated with LGGs. Importantly, given that LGGs frequently have an indolent clinical history, the subjects were followed up for sufficiently long periods to accurately evaluate overall survival.

Free Research Field

脳腫瘍

Academic Significance and Societal Importance of the Research Achievements

低悪性度神経膠腫におけるDMBT1及びMET遺伝子の機能について、他に同様の報告はされていない。本研究において、DMBT1及びMET 遺伝子とgrade IIIグリオーマ細胞株の相互作用や悪性転化・増殖に関わる機能解析を行ったことで、腫瘍発生・進展・増殖及び悪性転化に関わるメカニズムの解明につながる。今後、難治性腫瘍である悪性グリオーマに対する新たな治療戦略の一つとして期待され、個別化医療の実現を可能にするバイオマーカーとなる可能性を秘めている。