Mechanism of neuroprotective effect of radiation therapy combined with hyperbaric oxygen therapy.

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K10900
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: University of the Ryukyus
• Principal Investigator: Katagiri Chiaki 琉球大学, 医学(系)研究科(研究院), 助教 (00443664)
• Co-Investigator(Kenkyū-buntansha): 石内 勝吾 琉球大学, 医学(系)研究科(研究院), 教授 (10312878) ; 菅原 健一 琉球大学, 病院, 講師 (50375573)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 高気圧酸素 / HBO / 放射線照射

Outline of Final Research Achievements

The standard treatment for malignant glioma is irradiation therapy, which is a combination of surgical removal of the tumor and postoperative chemotherapy, but irradiation has the side effect of reducing the patient's cognitive function as a side effect. In this study, we investigated the mechanism by which radiation therapy combined with hyperbaric oxygen therapy shows a neuroprotective effect on cognitive decline caused by irradiation. Radiation therapy combined with HBO was found to prevent cognitive decline by reducing neuropathy caused by radiation to white matter neurons and oligodendrocytes.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

悪性神経膠腫の術後療法のひとつ放射線照射療法は、照射部位にもよるが副作用として認知機能低下をもたらす。本研究では放射線による神経損傷、それに伴う認知機能低下に対して高気圧酸素療法併用法が神経細胞に対しての保護作用を示し認知機能低下を予防することを示した。今後、患者のQOLを重視する治療戦略として認知機能保護を考慮した放射線療法を行うためにも本研究で得られた知見は有用である。