2019 Fiscal Year Final Research Report
Exploration of molecular biomarker for early prognostification of spinal cord injury
| Project/Area Number |
17K10921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Koda Masao 筑波大学, 医学医療系, 准教授 (50361449)
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| Co-Investigator(Kenkyū-buntansha) |
古矢 丈雄 千葉大学, 医学部附属病院, 講師 (00507337)
佐藤 守 千葉大学, 医学部附属病院, 特任准教授 (20401002)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 分子バイオマーカー / 脊髄損傷 / プロテオミクス |
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| Outline of Final Research Achievements |
We explored the candidates for molecular biomarkers to determine injury severity and to predict neurological prognosis in acute phase of spinal cord injury (SCI) by proteomics approach. Excitatory amino acid transporter 1 (EAAT1) and Myelin-associated glycoprotein (MAG) were picked up as possible candidates for molecular biomarkers.
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| Free Research Field |
脊椎脊髄外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた分子バイオマーカー候補物質を、さらなる妥当性検証にてヒト脊髄損傷患者さんへの応用を目指す。現在のところ有効なバイオマーカーがない急性期脊髄損傷におけるバイオマーカーを開発できれば、エビデンスに基づいた治療体系構築に非常に有用である。
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