The impact of irradiation on spinal dural mater

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10927
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kanazawa University
• Principal Investigator: Murakami Hideki 金沢大学, 医学系, 協力研究員 (70334779)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 放射線障害 / 脊椎腫瘍 / 硬膜 / 硬膜内浸潤

Outline of Final Research Achievements

Surprisingly, after radiation exposure, some spinal tumors invade into the dura mater resulting in poor surgical and oncological outcomes. We hypothesized that radiation exposure may result in the disruption of the protections offered by the spinal dura mater. The purpose of this study was to investigate post-irradiation changes in the spinal dura mater in mice.
Intra-dural tumor invasion and disruptions of the dural microstructure were observed in the meninges of mice post-irradiation, indicating radiation-induced disruption of the dural barrier function. Disruption of dural barrier function should be acknowledged as one of the radiation-induced injuries.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

今後の更なるがん治療の進歩に伴い、脊椎腫瘍に対する放射線照射後に長期生存する例が増加していくと考えられる。本研究で初めて示された放射線障害である硬膜バリア機構の破綻によって悪性腫瘍の硬膜内浸潤が発生すると、腫瘍の局所制御のみならず、生命予後・機能予後も極めて不良となる。そのため、本研究で得られた知見は背椎腫瘍の治療戦略において考慮すべき重要な要素となる。